Oakleigh Ryan Nance, an Oklahoma infant born prematurely at three pounds, is facing serious kidney and heart conditions complicated by recurring bacterial infections. After spending time in neonatal intensive care, she appeared healthy for about six months before developing a high fever and a severe urinary tract infection. The fever returned after antibiotic treatment, and further testing revealed stage 3 kidney reflux.

Oakleigh’s left kidney has 22% function and consists of two kidneys with separate ureters. Doctors scheduled an approximately four-and-a-half-hour operation to correct the reflux and reduce the risk of future infections. They also plan to remove a pocket on the outside of the kidney. Tests during her hospitalization revealed a moderate atrial septal defect and pulmonary stenosis; after she recovers from kidney surgery, her family plans to consult a cardiologist about further testing.

Her infections have included an antibiotic-resistant strain of Pseudomonas, and a later report said the 11-month-old had also been diagnosed with a critical, drug-resistant strain of E. coli. Her family said the E. coli infection posed serious risks and that her previous exposure to antibiotics had limited treatment options. The family did not know how she contracted it, and the Centers for Disease Control and Prevention was investigating. They hoped she could overcome the infection before her kidney surgery, reported as scheduled for the second week in August.

Pseudomonas bacteria are common and may cause minor illnesses such as swimmer’s ear or a hot tub rash. In people who are ill or weakened, however, they can cause serious infections in the lungs, blood, urinary tract or other parts of the body. These infections can be difficult to treat because the bacteria may resist multiple antibiotics. Severe infection spreading through the bloodstream can cause high fever, chills, confusion and shock.

Oakleigh’s family describes her as a spirited child and draws strength from its faith and the support of loved ones. The family has also sought donations to help cover her medical expenses.