Toronto police are investigating the suspicious deaths of billionaire pharmaceutical entrepreneur Barry Sherman, 75, and his wife, Honey Sherman, 70. The couple were found dead Friday at their North York mansion, reportedly by a real estate agent handling the sale of the property. Their bodies were found hanging from a railing near their indoor pool.

Police said both died from “ligature neck compression” and that homicide detectives had taken over the investigation. They reported no signs of forced entry and said they were not searching for any outstanding suspects. Police had not determined whether foul play was involved and continued to classify the deaths as suspicious.

Some news reports, citing police sources, said investigators were considering a murder-suicide. The Shermans’ four adult children rejected that suggestion, saying their parents’ enthusiasm for life and commitment to their family and community were inconsistent with the reports. Friends and colleagues also expressed disbelief. Shortly before her death, Honey had emailed friends about the couple’s upcoming Florida trip and plans to see them there. The couple had recently welcomed a grandchild.

Barry Sherman founded generic-drug company Apotex in 1974 and built it into an international business. Canadian Business recently estimated his net worth at $4.77 billion, ranking him among Canada’s wealthiest people. Friends described him as reserved and intensely devoted to his work; an acquaintance said he had recently spoken enthusiastically about the business and had no plans to leave it. Toronto Mayor John Tory praised Sherman for creating jobs and keeping Apotex operations in the city.

Honey Sherman was remembered as outgoing, sociable and deeply involved in philanthropy. The couple donated millions of dollars to hospitals, universities and Jewish causes. She served on boards associated with York University, Baycrest and Mount Sinai Hospital, among other organizations, and held leadership roles in Toronto’s Jewish community.

The deaths shocked friends, employees and neighbours. Flowers accumulated at a memorial outside the home, while tributes came from political and community leaders. The circumstances surrounding the couple’s deaths remained unresolved.